Fibronectin unfolded by adherent but not suspended platelets: An in vitro explanation for its dual role in haemostasis
Fibronectin
(FN), a dimeric adhesive glycoprotein, which is present both in plasma and the
extracellular matrix can interact with platelets and thus contribute to
platelet adhesion and aggregation.
It
has been shown that FN can decrease platelet aggregation but enhance platelet
adhesion, suggesting a dual role of FN in haemostasis.
The
prevalent function(s) of FN may be determined by its fibril form. To explore
the suggested dual role of this adhesive protein for haemostasis in further
detail, we now tested for any differences of adherent and suspended platelets
with regard to their effect to unfold and assemble FN upon interaction.
Title:
| Fibronectin unfolded by adherent but not suspended platelets: An in vitro explanation for its dual role in haemostasis | |
| Authors: | Huynh, Khon Gyenes, Marianna Hollenberg, Cornelis P. |
| Keywords: | Fibronectin platelet adhesion and aggregation fibronectin assembly fibronectin unfolding and fibril formation |
| Issue Date: | 2015 |
| Publisher: | Đại học Quốc gia Hà Nội |
| Citation: | ISIKNOWLEDGE |
| Abstract: | Fibronectin (FN), a dimeric adhesive glycoprotein, which is present both in plasma and the extracellular matrix can interact with platelets and thus contribute to platelet adhesion and aggregation. It has been shown that FN can decrease platelet aggregation but enhance platelet adhesion, suggesting a dual role of FN in haemostasis. The prevalent function(s) of FN may be determined by its fibril form. To explore the suggested dual role of this adhesive protein for haemostasis in further detail, we now tested for any differences of adherent and suspended platelets with regard to their effect to unfold and assemble FN upon interaction. |
| Description: | THROMBOSIS RESEARCH Volume: 136 Issue: 4 Pages: 803-812 Published: OCT 2015 ; TNS05577 |
| URI: | http://repository.vnu.edu.vn/handle/VNU_123/27489 |
| Appears in Collections: | Bài báo của ĐHQGHN trong Web of Science |
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