Multifunctional drug nanosystems: A summary of recent researches at IMS/VAST
The
main task of nanomedicine is to fabricate, normally by chemical engineering,
nanoscale systems that can play various functions of both diagnosis and
treatment.
This
report aims to present some researches, carried out by the Laboratory of
Biomedical Nanomaterials (IMS/VAST in Hanoi), on fabrication and
characterization of nanovectors for the disease of cancer.
The
first part deals with magnetite (Fe3O4) nanoparticles (MNPs) based
nanoconjugates, functionalized by coating with several polymers as well as
loaded with a drug of curcumin. The used MNPs were obtained by coprecipitation,
exhibited spherical shape of diameter of 15-20 nm, saturation magnetization of
Ms ~ 65-70 emu/g.
The
coating polymers were acrylic acid (PAA), chitosan (CS) and Alginate (Alg)
which were confirmed using the infrared (FTIR) spectra. Magnetic Inductive
Heating (MIH) measurements demonstrated that the fabricated MNPs-based
conjugates exhibited quite high heating performance, perspective for
hyperthermia application. The application of Fe3O4@PAA for in-vivo hyperthermia
treatment of cancer incubated on mice will be shown.
As
for imaging application, the Fe3O4@CS@Cur was used to demonstrate a dual
possibilities, fluorescence and magnetic resonance, of monitoring cell
penetration by macrophage. In the second part, we show a recent study on
targeted delivery systems of paclitaxel/doxorubicin/curcumin-loaded
copolymer/polymer nanoparticles, which were prepared by a modified solvent
extraction/evaporation technique and decorated by folic acid.
The
obtained spherical nanoparticles were negatively charged with a zeta potential
of about − 30 mV with the size around 50 nm and a narrow size distribution. The
targeting effect of anticancer-drugs nanoparticles with folate decoration was
investigated in vitro by the uptake in cancer cell lines and in nude mouse.
The
results indicate that the targeted paclitaxel/doxorubicin/curcumin-loaded
copolymer/polymer nanoparticles are successful anticancer-targeted drug
delivery system for effective cancer chemotherapy.
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